Disease/Relevance: T. cruzi is a parasitic protozoan that bores tissue in other organisms and feeds on their blood and lymph, causing Chagas disease. The parasite is transmitted through insect vectors, such as bites, stings, or feces. Common symptoms of Chagas disease are fever, fatigue, headaches, and swollen glands.
Location:
In the digestive vacuoles of the parasitic trypanosome and contributes to the nutrition of the organism by digestion of host proteins.
Belongs to peptidase family C1
Type of Enzyme: Phosphatase Brenda E.C.: 3.1.3.16 Structure: 2 models on ModBase Activity from Brenda: None Druggability: 0.6 Assay: Been done TDR Targets Link:
Gene/Ortholog: Tb927.10.6460 (OG4_10634); Phenotype: no significant loss or gain of fitness in bloodstream forms (3 days); Source study: alsford
Gene/Ortholog: Tb927.10.6460 (OG4_10634); Phenotype: significant loss of fitness in bloodstream forms (6 days); Source study: alsford
Gene/Ortholog: Tb927.10.6460 (OG4_10634); Phenotype: significant loss of fitness in procyclic forms; Source study: alsford
Gene/Ortholog: Tb927.10.6460 (OG4_10634); Phenotype: significant loss of fitness in differentiation of procyclic to bloodstream forms; Source study: alsford
T. cruzi is a parasitic protozoan that bores tissue in other organisms and feeds on their blood and lymph, causing Chagas disease. The parasite is transmitted through insect vectors, such as bites, stings, or feces. Common symptoms of Chagas disease are fever, fatigue, headaches, and swollen glands.
Location:
In the digestive vacuoles of the parasitic trypanosome and contributes to the nutrition of the organism by digestion of host proteins.
Belongs to peptidase family C1
Type of Enzyme: Phosphatase
Brenda E.C.: 3.1.3.16
Structure: 2 models on ModBase
Activity from Brenda: None
Druggability: 0.6
Assay: Been done
TDR Targets Link:
http://tdrtargets.org/targets/view?gene_id=39227
Inhibitors: None
Essentiality:
Gene/Ortholog: Tb927.10.6460 (OG4_10634); Phenotype: no significant loss or gain of fitness in bloodstream forms (3 days); Source study: alsford
Gene/Ortholog: Tb927.10.6460 (OG4_10634); Phenotype: significant loss of fitness in bloodstream forms (6 days); Source study: alsford
Gene/Ortholog: Tb927.10.6460 (OG4_10634); Phenotype: significant loss of fitness in procyclic forms; Source study: alsford
Gene/Ortholog: Tb927.10.6460 (OG4_10634); Phenotype: significant loss of fitness in differentiation of procyclic to bloodstream forms; Source study: alsford